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Am J Psychiatry 1985; 142:356-358
Copyright © 1985 by American Psychiatric Association

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Biochemical RBC abnormalities in drug-free and lithium-treated manic patients

RS Jope, LC Tolbert, SM Wright and W Walter-Ryan

RBCs from two lithium-free manic patients displayed lower choline transport and higher choline concentrations and methionine S- adenosyltransferase activity than those of controls. Lithium therapy decreased RBC methionine S-adenosyltransferase activity to normal, decreased choline transport further, and increased choline concentrations further.




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