Open trial of S-adenosylmethionine for treatment of depression



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Am J Psychiatry 1984; 141:448-450
Copyright © 1984 by American Psychiatric Association

REGULAR ARTICLES

Open trial of S-adenosylmethionine for treatment of depression

JF Lipinski, BM Cohen, F Frankenburg, M Tohen, C Waternaux, R Altesman, B Jones and P Harris

Nine depressed inpatients completed trials with S-adenosylmethionine. Seven showed improvement or remission of their symptoms. As in European studies, no side effects were seen except the apparent induction of mania in two patients with bipolar disorder.

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