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Am J Psychiatry 1984; 141:357-362
Copyright © 1984 by American Psychiatric Association


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Biopsychobehavioral correlates of insomnia. IV: Diagnosis based on DSM- III

TL Tan, JD Kales, A Kales, CR Soldatos and EO Bixler

DSM-III diagnoses were established for 100 patients with chronic insomnia. Principal and additional diagnoses on axis I and II (psychiatric and personality disorders) were extremely prevalent. Only five patients had a principal diagnosis on axis III (physical disorders). The most common diagnoses on axis I were dysthymic, anxiety, somatoform, and substance use disorders. Compulsive personality disorder or trait was the most common axis II diagnosis. Ninety-five patients had multiple diagnoses. This study confirms that patients with chronic insomnia have a high prevalence of psychopathology and characteristic internalizing patterns of anxiety, depression, obsessive-compulsiveness, phobia, and excessive somatic concerns.


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A. N. Vgontzas, E. O. Bixler, H.-M. Lin, P. Prolo, G. Mastorakos, A. Vela-Bueno, A. Kales, and G. P. Chrousos
Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications
J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3787 - 3794.
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