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Am J Psychiatry 1984; 141:1612-1613
Copyright © 1984 by American Psychiatric Association

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Alprazolam-related digoxin toxicity

G Tollefson, T Lesar, D Grothe and M Garvey

An elderly woman developed a high serum digoxin concentration resulting in toxicity when alprazolam was added to her digoxin therapy. The reduced renal clearance of digoxin is postulated as the mechanism for this interaction.




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