CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by Gerner, R. H.
	Articles by Cohen, D. J.
	Search for Related Content



	PubMed Citation
	Articles by Gerner, R. H.
	Articles by Cohen, D. J.

Am J Psychiatry 1984; 141:1533-1540
Copyright © 1984 by American Psychiatric Association

REGULAR ARTICLES

CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls

RH Gerner, L Fairbanks, GM Anderson, JG Young, M Scheinin, M Linnoila, TA Hare, BA Shaywitz and DJ Cohen

A total of 114 subjects (41 depressed, 20 schizophrenic, 15 manic, and 38 normal controls) underwent lumbar puncture and their CSF was analyzed for levels of tyrosine, tryptophan, homovanillic acid (HVA), 5- hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), choline, gamma-aminobutyric acid (GABA), and calcium. Results showed that depressed patients, particularly those over 40 years of age, had lower levels of GABA than did controls, and that their level of HVA increased with age, while controls' decreased. Schizophrenic subjects tended to have higher levels of 5-HIAA and manic subjects tended to have higher levels of HVA and MHPG. Age-associated changes were found in HVA, 5-HIAA, MHPG, GABA, and choline concentrations.

This article has been cited by other articles:

G. Sanacora, R. Gueorguieva, C. N. Epperson, Y.-T. Wu, M. Appel, D. L. Rothman, J. H. Krystal, and G. F. Mason
Subtype-Specific Alterations of {gamma}-Aminobutyric Acid and Glutamate in Patients With Major Depression
Arch Gen Psychiatry, July 1, 2004; 61(7): 705 - 713.
[Abstract] [Full Text] [PDF]

L. N. Yatham, P. F. Liddle, I-S. Shiah, R. W. Lam, E. Ngan, G. Scarrow, M. Imperial, J. Stoessl, V. Sossi, and T. J. Ruth
PET Study of [18F]6-Fluoro-L-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium
Am J Psychiatry, May 1, 2002; 159(5): 768 - 774.
[Abstract] [Full Text] [PDF]

J. J. Mann, Y.-y. Huang, M. D. Underwood, S. A. Kassir, S. Oppenheim, T. M. Kelly, A. J. Dwork, and V. Arango
A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide
Arch Gen Psychiatry, August 1, 2000; 57(8): 729 - 738.
[Abstract] [Full Text] [PDF]

G. Sanacora, G. F. Mason, D. L. Rothman, K. L. Behar, F. Hyder, O. A. C. Petroff, R. M. Berman, D. S. Charney, and J. H. Krystal
Reduced Cortical {gamma}-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy
Arch Gen Psychiatry, November 1, 1999; 56(11): 1043 - 1047.
[Abstract] [Full Text] [PDF]

Get information about faster international access.