Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome



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	Articles by Liu, S. J.
	Articles by Wang, R. I.

Am J Psychiatry 1984; 141:1287-1288
Copyright © 1984 by American Psychiatric Association

REGULAR ARTICLES

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome

SJ Liu and RI Wang

A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma methadone level must be monitored.

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