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Am J Psychiatry 1984; 141:103-104
Copyright © 1984 by American Psychiatric Association

REGULAR ARTICLES

Behavioral change in a cancer patient following intrathecal beta- endorphin administration

D Pickar, M Dubois and MR Cohen

A patient with a disseminated malignancy received 3 mg of synthetic beta-endorphin administered intrathecally by lumbar puncture. A marked behavioral syndrome characterized by confusion, hypomanic/manic behavior, and psychosis followed drug administration and persisted for more than 2 days.




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