Am J Psychiatry 1983; 140:1437-1442
Copyright © 1983 by American Psychiatric Association
Familial relatedness of schizophrenia and schizotypal states
M Baron, R Gruen, L Asnis and J Kane
The types and expectancy of mental disorders in the siblings of 74 probands
with chronic schizophrenia were examined. The siblings were classified
according to whether 1) both parents had schizotypal personality disorder,
2) one parent had the disorder and one was normal, or 3) both parents were
normal. Siblings whose parents both had the disorder were at significantly
greater risk for schizophrenia and schizotypal personality disorder than
siblings with at least one normal parent. Similarly, the expectancy of
schizotypal personality disorder alone and combined with schizophrenia was
higher among siblings with one parent with the disorder than in siblings
with two normal parents. The data suggest that schizotypal traits may be
genetically related to schizophrenia.
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