Am J Psychiatry 1982; 139:1178-1180
Copyright © 1982 by American Psychiatric Association
Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine
CT Gualtieri, WH Lefler, M Guimond and JI Staye
Of 18 mentally retarded institutionalized subjects who had received
long-term, high-dose treatment primarily with thioridazine or
chlorpromazine, 2 developed definite corneal and lenticular opacities and 2
had equivocal ocular changes. In view of this finding, the authors suggest
that alternative treatment, including different neuroleptics, be considered
with mentally retarded institutionalized subjects; when that is not
possible, subjects should be given periodic evaluation, including annual
slit-lamp examination.
