Am J Psychiatry 1982; 139:1170-1174
Copyright © 1982 by American Psychiatric Association
Efficacy of antipsychotic medications in behaviorally disturbed dementia patients
R Barnes, R Veith, J Okimoto, M Raskind and G Gumbrecht
This study compared the therapeutic efficacy of thioridazine, loxapine, and
a placebo in the treatment of behavioral disturbances in nursing home
patients with dementia. Antipsychotic medications were effective for the
specific behavioral problems of anxiety, excitement, emotional lability,
and uncooperativeness. Subjects with the most severe symptoms at baseline
assessment derived the greatest benefit from treatment. Sedation,
extrapyramidal symptoms, and decreased blood pressure were common side
effects among patients treated with the antipsychotic drugs. The authors
conclude that antipsychotic medication has a definite but limited
therapeutic role in the treatment of behavioral disturbances in nursing
home patients with dementia.
This article has been cited by other articles:
|
|
|
|
 
R. L. Maher Jr
The Pharmacological Approach of Behavioral Disturbances in Dementia
Journal of Pharmacy Practice,
April 1, 2004;
17(2):
129 - 132.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. A. Banks and J. E. Morley
Memories Are Made of This: Recent Advances in Understanding Cognitive Impairments and Dementia
J. Gerontol. A Biol. Sci. Med. Sci.,
April 1, 2003;
58(4):
M314 - 321.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Mayeux and M. Sano
Treatment of Alzheimer's Disease
N. Engl. J. Med.,
November 25, 1999;
341(22):
1670 - 1679.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. McKenzie, J. P. Mullooly, B. H. McFarland, J. A. Semradek, and L. E. McCamant
Changes in Antipsychotic Drug Use Following Shifts in Policy: A Multilevel Analysis
Research on Aging,
March 1, 1999;
21(2):
304 - 337.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.P. Devanand, K. Marder, K. S. Michaels, H. A. Sackeim, K. Bell, M. A. Sullivan, T. B. Cooper, G. H. Pelton, and R. Mayeux
A Randomized, Placebo-Controlled Dose-Comparison Trial of Haloperidol for Psychosis and Disruptive Behaviors in Alzheimer's Disease
Am J Psychiatry,
November 1, 1998;
155(11):
1512 - 1520.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
V. Rao and C. G. Lyketsos
Delusions in Alzheimer's Disease: A Review
J Neuropsychiatry Clin Neurosci,
November 1, 1998;
10(4):
373 - 382.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. McShane, J. Keene, K. Gedling, C. Fairburn, R. Jacoby, and T. Hope
Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up
BMJ,
January 25, 1997;
314(7076):
266 - 266.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D.P. Devanand and S. R. Levy
Neuroleptic Treatment of Agitation and Psychosis in Dementia
J Geriatr Psychiatry Neurol,
October 1, 1995;
8(1):
S18 - S27.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. L. Spore, A. L. Horgas, M. A. Smyer, and L. N. Marks
The Relationship of Antipsychotic Drug Use, Behavior, and Diagnoses among Nursing Home Residents
J Aging Health,
November 1, 1992;
4(4):
514 - 535.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. J. Flint
Delusions, hallucinations and depression in Alzheimer's disease: A biological perspective
American Journal of Alzheimer's Disease and Other Dementias,
May 1, 1991;
6(3):
21 - 28.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. D. Burgio and A. M. Hawkins
Behavioral Assessment of the Effects of Psychotropic Medications on Demented Nursing Home Residents
Behav Modif,
April 1, 1991;
15(2):
194 - 212.
[Abstract]
|
|
|
|
|
|
|
E. H. Rubin, W. C. Drevets, and W. J. Burke
The Nature of Psychotic Symptoms in Senile Dementia of the Alzheimer Type
J Geriatr Psychiatry Neurol,
January 1, 1988;
1(1):
16 - 20.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1982
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
