Am J Psychiatry 1982; 139:1170-1174
Copyright © 1982 by American Psychiatric Association
Efficacy of antipsychotic medications in behaviorally disturbed dementia patients
R Barnes, R Veith, J Okimoto, M Raskind and G Gumbrecht
This study compared the therapeutic efficacy of thioridazine, loxapine, and
a placebo in the treatment of behavioral disturbances in nursing home
patients with dementia. Antipsychotic medications were effective for the
specific behavioral problems of anxiety, excitement, emotional lability,
and uncooperativeness. Subjects with the most severe symptoms at baseline
assessment derived the greatest benefit from treatment. Sedation,
extrapyramidal symptoms, and decreased blood pressure were common side
effects among patients treated with the antipsychotic drugs. The authors
conclude that antipsychotic medication has a definite but limited
therapeutic role in the treatment of behavioral disturbances in nursing
home patients with dementia.
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