|
| | |
|
Am J Psychiatry 1982; 139:991-997
Copyright © 1982 by American Psychiatric Association
d-Amphetamine-induced heterogeneous changes in psychotic behavior in schizophrenia
DP van Kammen, WE Bunney Jr, JP Docherty, SR Marder, MH Ebert, JE Rosenblatt and JN Rayner
In this placebo-paired, double-blind study, 13 of 45 schizophrenic patients
showed an acute improvement in schizophrenic symptoms following
d-amphetamine infusion (20 mg). The 18 patients who worsened tended to have
higher CSF 3-methoxy-4-hydroxyphenylglycol levels than did those who
improved. d-Amphetamine blood levels and clinical descriptors of
schizophrenic subgroups did not differentiate patients who improved from
those who worsened; however, patients who improved had been significantly
more psychotic before the infusion. Patients who worsened had been more
psychotic than those who did not change. The authors suggest that those who
did not change. The authors suggest that sensitivity to dopamine
stimulation in schizophrenia is state-dependent rather than trait-dependent
and that the simple, undirectional hypothesis of schizophrenia needs to be
reformulated.
This article has been cited by other articles:
|
|
|
|
 
C. Curran, N. Byrappa, and A. Mcbride
Stimulant psychosis: systematic review
The British Journal of Psychiatry,
September 1, 2004;
185(3):
196 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Devous, M. H. Trivedi, and A. J. Rush
Regional Cerebral Blood Flow Response to Oral Amphetamine Challenge in Healthy Volunteers
J. Nucl. Med.,
April 1, 2001;
42(4):
535 - 542.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Laruelle and A. Abi-Dargham
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
J Psychopharmacol,
July 1, 1999;
13(4):
358 - 371.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D.G.C. Owens, P.E. Harrison-Read, and E. C. Johnstone
L-dopa helps positive but not negative features of neuroleptic-insensitive chronic schizophrenia
J Psychopharmacol,
January 1, 1994;
8(4):
204 - 212.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. J. Chiarello and J. O. Cole
The Use of Psychostimulants in General Psychiatry: A Reconsideration
Arch Gen Psychiatry,
March 1, 1987;
44(3):
286 - 295.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. P. van Kammen, W. B. van Kammen, L. S. Mann, T. Seppala, and M. Linnoila
Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy
Arch Gen Psychiatry,
October 1, 1986;
43(10):
978 - 983.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Linnoila, P. T. Ninan, M. Scheinin, R. N. Waters, W.-H. Chang, J. Bartko, and D. P. van Kammen
Reliability of Norepinephrine and Major Monoamine Metabolite Measurements in CSF of Schizophrenic Patients
Arch Gen Psychiatry,
December 1, 1983;
40(12):
1290 - 1294.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila
Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy
Science,
May 27, 1983;
220(4600):
974 - 977.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1982
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
