Am J Psychiatry 1982; 139:753-757
Copyright © 1982 by American Psychiatric Association
Schizophrenia and cerebral asymmetry detected by computed tomography
DJ Luchins, DR Weinberger and RJ Wyatt
The authors nonblindly assessed occipital cerebral asymmetry on computed
tomography (CT) scans of 79 schizophrenic or schizoaffective patients and
100 neurological or medical patients. More of the schizophrenic patients
had reversals of the normal asymmetry than did controls. The schizophrenics
with CT evidence of brain atrophy has a higher frequency of normal
asymmetrics than did controls, and the schizophrenics without atrophy had
more reversed asymmetries. The schizophrenics with reversed asymmetry,
compared with those with normal asymmetry, had lower verbal than
performance IQ. Comparison of occipital asymmetry and lateral ventricular
asymmetry indicated that reversed asymmetry in the schizophrenic patients
was probably not due to localized atrophy.
