Pharmacology of hallucinations induced by long-term drug therapy



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	Articles by Goetz, C. G.
	Articles by Klawans, H. L.

Am J Psychiatry 1982; 139:494-497
Copyright © 1982 by American Psychiatric Association

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Pharmacology of hallucinations induced by long-term drug therapy

CG Goetz, CM Tanner and HL Klawans

The authors studied 20 patients with Parkinson's disease and prominent hallucinations related to dopaminergic or anticholinergic therapy. The character of the hallucinations appeared distinct from the classic description of either acute anticholinergic or acute aminergic hallucinatory states. Manipulation of either kind of drug could precipitate or relieve hallucinations in a given patient, which suggests that the dopaminergic/cholinergic systems are reciprocally active in the pathophysiology of long-term drug-induced hallucinatory states in this population.

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