Am J Psychiatry 1982; 139:485-488
Copyright © 1982 by American Psychiatric Association

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Effects of d-amphetamine on urinary metabolites of dopamine and norepinephrine in hyperactive boys

WO Shekim, J Javaid, H Dekirmenjian, JL Chapel and JM Davis

The authors measured the urinary metabolites 3-methoxy-4- hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in 21 hyperactive boys and 12 matched healthy boys. The hyperactive boys excreted lower amounts of MHPG than control boys. Hyperactive drug responders excreted lower amounts of HVA than control boys and hyperactive nonresponders. Drug responders with normal MHPG excreted low amounts of HVA and those with normal HVA excreted low amounts of MHPG. d-Amphetamine decreased MHPG in all drug responders and HVA in drug responders with normal HVA levels, although it tended to increase HVA in those with low HVA levels. The authors discuss their data in terms of the possible involvement of norepinephrine and dopamine in the etiology of hyperactivity in children.

This article has been cited by other articles:

				W. O. Shekim, E. Sinclair, R. Glaser, E. Horwitz, J. Javaid, and D. B. Bylund Norepinephrine and Dopamine Metabolites and Educational Variables in Boys With Attention Deficit Disorder and Hyperactivity J Child Neurol, January 1, 1987; 2(1): 50 - 56. [Abstract] [PDF]

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