Am J Psychiatry 1982; 139:1447-1454
Copyright © 1982 by American Psychiatric Association
Effects of thioridazine and withdrawal dyskinesias on workshop performance of mentally retarded young adults [retracted in Am J Psychiatry 1989 May;146(5):634]
SE Breuning, VJ Davis, JL Matson and DG Ferguson
The authors conducted a two-part study of the effects of thioridazine and
withdrawal dyskinesias on the workshop performance of mentally retarded
young adults. In part 1, 80 mentally retarded subjects were divided into
five groups of 16 according to administration, discontinuation, or
nonadministration of thioridazine. The major finding was that thioridazine
can impair the workshop performance of mentally retarded individuals. In
part 2, 28 subjects were divided into four matched groups of 7 subjects
each whose thioridazine dose was abruptly or gradually discontinued and who
did or did not have withdrawal dyskinesias. Workshop performance declined
with the onset of the dyskinesias and improved as the dyskinesias subsided.
