Am J Psychiatry 1981; 138:1098-1101
Copyright © 1981 by American Psychiatric Association
CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa
RH Gerner and TA Hare
The authors examined the CSF GABA of 87 subjects: 29 normal control
subjects, 11 patients with schizophrenia, 26 with depression, 6 with mania,
and 15 with anorexia nervosa. Depressed patients had significantly lower
CSF GABA levels than did normal subjects. This finding suggests that GABA
may have a direct or indirect association with depressive affective
disorders.
