Withdrawal symptoms after graduated cessation of imipramine in children



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	Articles by Law, W., 3d
	Articles by Kazdin, A. E.

Am J Psychiatry 1981; 138:647-650
Copyright © 1981 by American Psychiatric Association

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Withdrawal symptoms after graduated cessation of imipramine in children

W Law 3d, TA Petti and AE Kazdin

In a systematic retrospective study the authors reviewed charts of 22 depressed children on a clinical research unit who were withdrawn from high-dose imipramine. Significant withdrawal symptoms were found over seven symptom categories despite an average tapering period of 6.4 days. These results suggest that withdrawal symptoms in children may be much more prevalent and intense than previously recognized.

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