Am J Psychiatry 1981; 138:489-492
Copyright © 1981 by American Psychiatric Association
Lithium's effect of parathyroid hormone
BM Davis, A Pfefferbaum, S Krutzik and KL Davis
Lithium has been reported to raise serum calcium and lower serum phosphate
concentrations and to increase urinary calcium excretion. Because these
changes may be effects of parathyroid hormone (PTH), PTH was measured in 19
patients receiving lithium. PTH was significantly higher in these patients
than in 150 normal subjects. For all patients serum calcium concentrations
correlated significantly with serum lithium concentrations. These results
indicate that lithium may cause biochemical hyperparathyroidism. Secondary
hyperparathyroidism in certain patients with lithium nephrotoxicity is also
possible.