Am J Psychiatry 1981; 138:478-483
Copyright © 1981 by American Psychiatric Association
Animal models of schizophrenia
WT McKinney and EC Moran
The authors review some general issues concerning the development and use
of animal models of schizophrenia and present a summary of the criteria
necessary for validating models. They also describe some of the major
attempts at creating animal models of schizophrenia, including drug and
nondrug methods. They comment on the etiologic, phenomenologic, and
treatment relevance of the various systems and suggest approaches that
might produce improved animal models of schizophrenia.
