Am J Psychiatry 1981; 138:365-367
Copyright © 1981 by American Psychiatric Association
Relationship of serum haloperidol levels to clinical response in schizophrenic patients
JR Magliozzi, LE Hollister, KV Arnold and GM Earle
The authors treated 16 outpatients and 1 inpatient who had diagnoses of
schizophrenia in exacerbation with haloperidol as the sole neuroleptic
agent and obtained ratings of psychopathology and serum levels of
haloperidol. Improvement in schizophrenic symptoms measured by the Brief
Psychiatric Rating Scale was significantly greater in patients who had mean
haloperidol serum concentrations in the range of 8-18 ng/ml than in
patients whose mean haloperidol serum concentration fell outside this
range.
