Am J Psychiatry 1981; 138:1624-1625
Copyright © 1981 by American Psychiatric Association
Induction of rapid mood cycling during L-dopa treatment in a bipolar patient
GN Ko, JF Leckman and GR Heninger
The authors report a longitudinal case study of a woman with a history of
bipolar affective disorder in which L-dopa shortened the manic- depressive
cycle length when administered in a double-blind trial. This finding
suggests a dopaminergic mechanism specifically in changing the frequency of
cycling between depression and mania.
