Am J Psychiatry 1981; 138:1362-1365
Copyright © 1981 by American Psychiatric Association
Fluphenazine decanoate and tardive dyskinesia: a possible association
JG Csernansky, K Grabowski, J Cervantes, J Kaplan and JA Yesavage
The authors examined the charts of 22 outpatients who had received
intramuscular fluphenazine decanoate and oral fluphenazine hydrochloride to
assess the incidence of tardive dyskinesia. The severity of tardive
dyskinesia was assessed with the Abnormal Involuntary Movement Scale
(AIMS). Both the total dose and average daily dose of fluphenazine
decanoate correlated significantly with high AIMS scores. There were also
significant correlations of AIMS scores with total dose of antiparkinsonian
medication and total dose of other neuroleptics. Total dose of
antiparkinsonian medication correlated with total dose of fluphenazine
decanoate. The authors discuss the clinical and physiological implications
of these correlations.
