
Am J Psychiatry 1981; 138:1-13
Copyright © 1981 by American Psychiatric Association
The symptoms of major depressive illness
JC Nelson and DS Charney
The authors suggest that the common characteristics of various descriptions
of major depressive illness--endogenous, endogenomorphic, psychotic, and
melancholic--are an autonomous course, a need for biological treatment, and
a presumed alteration in neurochemistry. The literature is reviewed to
determine those symptoms which best characterize this syndrome. These
symptoms may prove useful in developing valid diagnostic criteria for major
depressive illness.
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