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Am J Psychiatry 1980; 137:921-927
Copyright © 1980 by American Psychiatric Association
"Schizoaffective disorder": an invalid diagnosis? A comparison of schizoaffective disorder, schizophrenia, and affective disorder
HG Pope Jr, JF Lipinski, BM Cohen and DT Axelrod
The authors compared patients meeting widely accepted criteria for the
diagnosis of schizoaffective disorder, manic type, with patients meeting
rigorous criteria for manic disorder and schizophrenia, using three methods
of validation: family history, short-term treatment response, and long-term
outcome. No significant differences were found between patients with manic
disorder and schizoaffective disorder. However, consistent and often highly
significant differences separated patients with schizophrenia from those
with manic disorder and schizoaffective disorder. The findings suggest that
schizoaffective disorder, as currently defined, is not a valid and
independent entity. The authors suggest that psychotic disorders not
diagnosable as manic- depressive illness or schizophrenia and without
apparent organic basis would best be called "undiagnosed" or "atypical"
psychosis. Further, while proposals for new diagnoses or for subtyping of
schizophrenia or manic-depressive illness should be encouraged, these
should undergo rigorous screening for validity before being accepted into
clinical use.
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