Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para- tyrosine and l-dopa



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	Articles by Wyatt, R. J.

Am J Psychiatry 1979; 136:311-313
Copyright © 1979 by American Psychiatric Association

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Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para- tyrosine and l-dopa

JR Tinklenberg, JC Gillin, GM Murphy Jr, R Staub and RJ Wyatt

Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.

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