Am J Psychiatry 1979; 136:1410-1414
Copyright © 1979 by American Psychiatric Association
Combined use of molindone and guanethidine in patients with schizophrenia and hypertension
LL Simpson
Human sympathetic nerves have a high-affinity norepinephrine uptake system.
This uptake system is inhibited competitively by chlorpromazine but not by
molindone, which suggests that molindone will not interact adversely with
guanethidine, an antihypertensive drug that enters sympathetic nerves via
the high-affinity uptake system. Accordingly, patients with concomitant
schizophrenia and hypertension were treated simultaneously with molindone
and guanethidine; there was no evidence of an adverse drug interaction. The
data indicate that molindone and guanethidine can be used in combination
safely and effectively.
