Am J Psychiatry 1979; 136:79-82
Copyright © 1979 by American Psychiatric Association
Factors related to tardive dyskinesia
G Chouinard, L Annable, A Ross-Chouinard and JN Nestoros
The authors found a 31% incidence of tardive dyskinesia among 261
schizophrenic outpatients treated with neuroleptics. Multiple linear
logistic regression analysis revealed a higher incidence of tardive
dyskinesia among elderly patients, those with longer records of
hospitalization, those for whom neuroleptic medication had little
therapeutic effect, and those treated with fluphenazine. Patients
manifesting tardive dyskinesia tended to have fewer parkinsonian symptoms
than those without the disorder, especially when tremors and akathisia were
excluded from consideration. Multiple linear regression analysis indicated
that brain-damaged patients and male patients were more susceptible to
severe forms of the disorder, even though these factors were not implicated
in its initial appearance.
