Am J Psychiatry 1978; 135:956-959
Copyright © 1978 by American Psychiatric Association
A controlled study of penfluridol in the treatment of chronic schizophrenia
YD Lapierre
Twenty patients were treated with penfluridol and 21 with fluphenazine for
a period of up to 1 year. Penfluridol, an oral neuroleptic administered
weekly was as efficacious as fluphenazine administered twice daily and
appeared to be superior to fluphenazine in improving emotional withdrawal
and anergia. The low incidence of side effects and other signs of toxicity,
coupled with an effective prophylactic activity, suggests that penfluridol
is an important addition to our therapeutic armamentarium for the treatment
of chronic schizophrenia.
