Am J Psychiatry 1978; 135:839-841
Copyright © 1978 by American Psychiatric Association
Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum
WC Friend, GM Brown, G Jawahir, T Lee and P Seeman
Prompted by an interest in the similarity of brain and tuberoinfundibular
systems, the authors studied butaclamol-specific neuroleptic and
apomorphine binding in pituitary and striatum after chronic haloperidol and
acute apomorphine treatment. Striatal binding increases but pituitary
binding decreases in haloperidol-treated rats. Pituitary binding changes
rapidly in response to apomorphine exposure and striatal binding does not.
These findings suggest that factors influencing binding differ in these two
tissues.
