Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report



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	Articles by Quitkin, F.
	Articles by Klein, D. F.

Am J Psychiatry 1978; 135:570-572
Copyright © 1978 by American Psychiatric Association

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Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report

F Quitkin, A Rifkin, J Kane, JR Ramos-Lorenzi and DF Klein

Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.

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