Am J Psychiatry 1978; 135:562-566
Copyright © 1978 by American Psychiatric Association
Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression
RH Ehrensing and AJ Kastin
Five of 8 patients with unipolar or bipolar endogenous depressions taking
prolyl-leucyl-glycinamide (MIF-I), 75 mg/day, showed substantial
improvement within a few days of beginning treatment compared with similar
improvement in only 1 of 10 receiving 750 mg/day of MIF-I and only 1 of 5
patients taking placebo. The lower dose of MIF-I was associated with
significantly greater improvement than both the higher dose and placebo on
all of the rating scales used. The authors suggest that an even lower dose
of MIF-I, on the order of 0.1 mg/kg, may have a greater effect as an
antidepressant.
