Am J Psychiatry 1978; 135:472-475
Copyright © 1978 by American Psychiatric Association
The effect of high doses of vitamin B6 on autistic children: a double- blind crossover study
B Rimland, E Callaway and P Dreyfus
The authors used data from an earlier nonblind study to identify 16
autistic-type child outpatients who had apparently improved when given
vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement
was replaced during two separate experimental trial periods with either a
B6 supplement or a matched placebo. Behavior was rated as deteriorating
significantly during the B6 withdrawal.
