Am J Psychiatry 1978; 135:470-472
Copyright © 1978 by American Psychiatric Association
Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine
J Davidson, MN McLeod and HL White
The authors treated 19 depressive inpatients double-blind with a mean dose
of 78 mg/day of phenelzine for 3 weeks to determine the possible
relationship between monoamine oxidase (MAO) inhibition and the
effectiveness of phenelzine. Clinical ratings made on the Hamilton
Depression Rating Scale, the Beck Depression Inventory, and the SCL-90
indicated a minimum of 60% MAO inhibition had to be achieved for the drug
to be consistently beneficial.
