Am J Psychiatry 1978; 135:1539-1542
Copyright © 1978 by American Psychiatric Association
Comparison of the incidence and severity of extrapyramidal side effects with fluphenazine enanthate and fluphenazine decanoate
J Kane, F Quitkin, A Rifkin and DF Klein
Forty-nine schizophrenic outpatients stabilized on oral antipsychotic
medication and procyclidine received 12.5 mg or 18.75 mg of fluphenazine
enanthate or fluphenazine decanoate and were examined for extrapyramidal
side effects one and two weeks later. Extrapyramidal side effects were
present in 30 patients (61%) but were clinically significant in only 11
(22%). Fluphenazine enanthate produced more clinically significant
extrapyramidal symptoms, particularly akathisia, than did fluphenazine
decanoate.
