Clozapine plasma levels and convulsions



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Am J Psychiatry 1978; 135:99-100
Copyright © 1978 by American Psychiatric Association

REGULAR ARTICLES

Clozapine plasma levels and convulsions

GM Simpson and TA Cooper

Two patients receiving clozapine developed grand mal seizures. The plasma levels in one of the patients at the time of the seizure were approximately 100% higher than on 12 previous occasions. This finding led to the conclusion and the patient's admission that she had taken an overdose. Plasma levels in the other patient exceeded the range the authors had noted in previous studies. The authors emphasize the usefulness of plasma level monitoring in relation to safety, drug defaulting, and side effects.

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