Am J Psychiatry 1977; 134:493-501
Copyright © 1977 by American Psychiatric Association
Psychoneuroendocrinology of affective disorder: an overview
PG Ettigi and GM Brown
Neuroendocrine function has been reported by several workers to be abnormal
in affective disorder. It has been shown that neurotransmitters
(noradrenaline, dopamine, and serotinin) are involved in the regulation of
neuroendocrine function. Several biological hypotheses of affective
disorder have implicated a defect in neurotransmitter function, but these
hypotheses have been found lacking in part over the years. The study of
neuroendocrine abnormalities found in various types of affective disorder
may clarify some aspects of this complex issue by reflecting
neurotransmitter activity in this disorder. Such studies should help
further explain affective illness.
