Am J Psychiatry 1976; 133:1073-1075
Copyright © 1976 by American Psychiatric Association
Anticholinergic exacerbation of phenothiazine-induced extrapyramidal syndrome
M Alpert, F Diamond and EM Laski
The authors used tremography to record the bilateral digital tremor of a
patient showing extrapyramidal system effects in response to withdrawal
from phenothiazines. They found that changes in the amplitude of tremor
correlated with clinical ratings of extrapyramidal disturbance. Changes in
the amplitude and in the spectrum of tremor were similar to the bipolar
paradoxical changes seen during intoxication with an anticholinergic
psychotogen.
