Am J Psychiatry 1976; 133:703-706
Copyright © 1976 by American Psychiatric Association
Low urinary dopamine and prediction of phenothiazine-induced Parkinsonism: a preliminary report
TJ Crowley, CO Rutledge, MM Hoehn, MA Stallings and S Sundell
Psychiatric patients who excreted larger amounts of urinary free dopamine
before treatment were significantly more likely than patients excreting
smaller amounts to develop parkinsonian side effects during moderate-dose
trifluoperazine therapy. If this finding is replicated, urinary free
dopamine determinations could prove valuable in indicating which patients
should receive those antipsychotic drugs least likely to produce
extrapyramidal side effects.
