Am J Psychiatry 1976; 133:208-214
Copyright © 1976 by American Psychiatric Association
Recent developments in the drug treatment of schizophrenia
JM Davis
The author reviews six topics relevant to the drug treatment of
schizophrenia. The quantitative effectiveness of promazine is of interest
with respect to the structural models of the phenothiazines and the
dopamine theory of schizophrenia. The quantitative effectiveness of
antipsychotic drugs is also important in evaluating new agents and
therefore relevant to a discussion of two newly released neuroleptics,
molindone and loxapine. The author's discussion of high- dose treatment of
typical acute schizophrenics or treatment-resistant patients reviews the
available data and calls attention to the fact that these areas of
pharmacologic research have not received sufficient attention.
