Am J Psychiatry 1975; 132:960-962
Copyright © 1975 by American Psychiatric Association
Steady-state protriptyline levels in an outpatient population
JT Biggs, WH Holland and WR Sherman
The authors measured steady-state protriptylive levels in 12 outpatients
undergoing treatment for depression. The steady-state level of
protriptyline was surprisingly high compared with levels obtained when
other tricyclic antidepressants were prescribed. This finding probably
accounts for the effectiveness of protriptyline at low doses and its
frequent side effects.
