Am J Psychiatry 1975; 132:907-910
Copyright © 1975 by American Psychiatric Association
Acute psychosis, increased water ingestion, and inappropriate antidiuretic hormone secretion
MA Raskind, H Orenstein and TG Christopher
The authors describe three postmenopausal women with agitated psychotic
depression, increased water ingestion, and electrolyte values consistent
with the syndrome of inappropriate antidiuretic hormone (ADH) secretion.
They hypothesize that this clinical triad represents a syndrome reflecting
underlying dysfunction of the hypothalamus and limbic system of the brain.
The diagnosis of inappropriate ADH in one of the patients was directly
confirmed by a recently developed serum radioimmunoassay.
