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Am J Psychiatry 1975; 132:870-871
Copyright © 1975 by American Psychiatric Association

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Amitriptyline-perphenazine overdose producing delayed hypomania in manic-depressive illness

EJ Mikkelsen and AH Rosebaum

The authors describe a 26-year-old woman who became hypomanic after awakening from a semicomatose state induced by an overdose of amitriptyline-perphenazine (Triavil). She had been depressed and had a strong family history of manic-depressive illness. The case is reported to support previous evidence that dopamine is a mediator for mania.




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