Am J Psychiatry 1975; 132:644-646
Copyright © 1975 by American Psychiatric Association
MMPI delineation of a subgroup of depressed patients refractory to lithium carbonate therapy
KM House and RL Martin
The authors found that in a sample of 26 severely depressed hospitalized
patients, 5 patients with low depression and psychasthenia profiles on the
Minnesota Multiphasic Personality Inventory did not show an antidepressant
response to lithium carbonate. Seventeen of 21 depressed patients with high
depression and psychasthenia profiles did respond to the antidepressant
effects of the drug. They tentatively conclue that by using the MMPI it is
possible to delineate a subgroup of depressed patients who are refractory
to lithium carbonate therapy.
