Am J Psychiatry 1975; 132:542-545
Copyright © 1975 by American Psychiatric Association
Imipramine and electrocardiographic abnormalities in hyperactive children
BG Winsberg, S Goldstein, LE Yepes and JM Perel
The authors report seven cases of electrocardiographic abnormalities
occurring in 7- to 10-year-old children receiving imipramine
pharmacotherapy for behavior disorders. Three of the children evidenced a
first-degree atrioventricular block. The abnormalities were less pronounced
in the other four children. Imipramine plasma levels during steady state
were not found to be directly related to the extent of the
electrocardiographic changes within the obtained plasma values. The authors
emphasize the necessity of careful clinical surveillance of children
receiving imipramine pharmacotherapy.
