Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone



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	Articles by Woody, G. E.
	Articles by Rickels, K.

Am J Psychiatry 1975; 132:447-450
Copyright © 1975 by American Psychiatric Association

REGULAR ARTICLES

Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone

GE Woody, CP O'Brien and K Rickels

Narcotic addicts may manifest symptoms of depression that aggravate their addiction. In this double-blind study of 35 mildly depressed patients in a methadone maintenance program, subjects who received doxepin improved significantly more than control subjects. Even in this short-term study, the reduction in depression was associated with a trend toward better performance in other areas of rehabilitation.

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