Am J Psychiatry 1975; 132:180-183
Copyright © 1975 by American Psychiatric Association
Affective disorder: studies with amine precursors
DL Dunner and RR Fieve
The authors assessed the clinical antidepressant effects of L- tryptophan
given alone and in combination with L-dopa in 12 patients with a diagnosis
of primary affective disorder; Preliminary results did not demonstrate an
antidepressant response when L-dopa was combined with L-tryptophan. Also,
the results did not support the catecholamine or biogenic amine hypotheses
of affective disorder.
