Doxepin: Is a Single Daily Dose Enough?
HAROLD L. GOLDBERG M.D.1,
RICHARD J. FINNERTY M.A.2, , and
JONATHAN O. COLE M.D.3
1 Director, West-Ros-Park Mental Health Center, Boston State Hospital and Associate Clinical Professor of Psychiatry, Boston University School of Medicine
2 Investigator, Psychopharmacology Research Group, Boston State Hospital and Clinical Instructor of Psychiatry, Tufts University School of Medicine
3 Research Consultant, Boston State Hospital and Psychiatrist to the McLean Hospital, Belmont, Mass., and Professor of Psychiatry, Tufts University School of Medicine
The authors conducted a post hoc comparison of two very similar doxepin studies that included outpatients with mixed anxiety and depression. The first study used a three-times-a-day schedule, and the second used a bedtime schedule. All differences between the two treatments favored the bedtime regimen. Although the reports cannot take the place of a direct comparison between the two dosage schedules, they offer evidence for the usefulness and value of single-dose bedtime medication for anxious-depressed outpatients receiving doxepin treatment.
