The Antagonism of Amphetamine-Induced Symptomatology by a Neuroleptic
B. ANGRIST M.D.,
H. K. LEE M.D.1, , and
S. GERSHON M.D.2
1 Director, Mental Health Clinic, Bronx-Lebanon Hospital Center, Bronx, N.Y.
2 Professor, Mental Health Clinic, Bronx-Lebanon Hospital Center, Bronx, N.Y.
A neuroleptic (haloperidol) that, in the doses used, is a specific blocker of dopamine was effective in antagonizing amphetamine-induced symptoms in eight patients. This finding suggests that dopaminergic mechanisms play an important role in amphetamine psychosis, as well as the additional possibility that these mechanisms may be important in other psychotic states.
