High-Dose Cyclazocine Therapy of Opiate Dependence
RICHARD RESNICK M.D.1,
MAX FINK M.D.2, , and
ALFRED M. FREEDMAN M.D.3
1 Assistant Professor and Director, Division of Drug Abuse Research and Treatment, Department of Psychiatry, New York Medical College, Flower and Fifth Avenue Hospitals, 5 East 102nd St., New York, N.Y. 10029
2 Professor and Chairman, Department of Psychiatry, New York Medical College, Flower and Fifth Avenue Hospitals, 5 East 102nd St., New York, N.Y. 10029
3 Professor of Psychiatry, Health Sciences Center, State University of New York at Stony Brook
Twenty-three former heroin addicts who had been stabilized on 4 to 5 mg. of cyclazocine per day had their dossage increased to 10 to 30 mg. per day. These increases resulted in mild, transient side effects. The narcotic-blocking activity of cyclazocine was extended to 48 hours by a daily dose of 10 mg. and to 72 hours by 20 mg. A daily dose of 3O mg. increased its blocking activity at 48 hours but not at 72 hours.
