The Treatment of Depression with a Single Daily Dose of Imipramine Pamoate
J. MENDELS M.D.1, and
JOSEPH DIGIACOMO M.D.2
1 Professor and Chief, Depression Research Unit, University of Pennsylvania, Philadelphia, Pa. and Philadelphia Veterans Administration Hospital, University and Woodland Aves., Philadelphia, Pa. 19104
2 Associate Professor, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa. and Philadelphia Veterans Administration Hospital, University and Woodland Aves., Philadelphia, Pa. 1910
A controlled comparison of the effects of 50 mg. of imipramine hydrochloride given three times daily and 150 mg. of imipramine pamoate in a single bedtime dose revealed no significant difference in either therapeutic effects or side effects in a group of 40 hospitalized depressed patients. The authors note the advantages of a single night dose of antidepressant medication.
